BioStruct-X

Full Name
Transnational access and enhancement of integrated Biological Structure determination at synchrotron X-ray radiation facilities
project coordination: EMBL, Hamburg, Germany

Start Date:
2011-09-01

End Date:
2015-08-31

Duration:
48 months

Grant Agreement No. / Project Reference No.
283570

Project Website
BIOSTRUCT-X

Abstract
The BioStruct-X consortium has 19 partners from 11 EU member and associated states, who lead in facility provision and research in structural biology using high brilliance X-rays, provided by state-of-the art synchrotrons and a free electron laser. BioStruct-X will provide integrated transnational access via 43 installations in four key areas: macromolecular X-ray crystallography, small angle X-ray scattering, X-ray imaging, protein production and high-throughput crystallisation. All installations provide on-line data analysis tools and remote experiment control.

Transnational access will be critically enhanced by four targeted joint research activities:
a) new data processing tools, to the benefit of access to applications in macromolecular X-ray crystallography;
b) an integrated on-line sample characterisation system, to the benefit of the access to small angle X-ray scattering,
c) correlated fluorescence light microscopy components that will enhance X-ray imaging applications offered for access;
d) a toolbox for mammalian cell line expression, to the direct benefit of the access to protein production facilities.

The BioStruct-X project will offer a central Batch Allocation Group proposal mechanism to promote project excellence by combining different methods and encouraging multi-site applications. The networking activity integrates all activities and combines them with those of other I3 actions under the ESFRI project INSTRUCT for future coordinated infrastructure activities in structural biology. The efficient management structure has four transparent layers: the coordinator, a six-member executive board, three work package coordinators and the general assembly comprising three user representatives and all partners. Thus, BioStruct-X will establish a state-of-the-art coordinated and multi-site infrastructure for current and emerging key methods in 21st century structural biology, thus advancing the European Research Area in biomedical sciences.

DESY Participation
WP4: TNA for x-ray Imaging (XI) Beamlines
WP6: Data Integration and Analysis for Synchrotron and FEL Crystallography
WP8: 3D Tomographic x-ray Imaging of Biological Cells
WP10: Integrated Networking Between TNA Providers, JRA Providers and the TNA User Community

Contact at DESY
Alke.Meents(at)DESY.de
Tel.: +49-40-8998-5468
Ute.Krell(at)DESY.de
Tel.: +49-40-8998-4508